7R1I

Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor

7R1I の概要

• エントリーDOI: 10.2210/pdb7r1i/pdb
• 関連するPDBエントリー: 7QKE 7QNN 7QWN
• 分子名称: Steroid C26-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ethyl 1-(2-piperidin-4-ylethyl)-5-pyridin-4-yl-indole-2-carboxylate, ... (6 entities in total)
• 機能のキーワード: cyp, 125, tuberculosis, inhibitor, cholesterol, oxidase, cyp125, p450, cytochrome, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 143804.68

構造登録者

Snee, M.,Katariya, M.,Levy, C.,Leys, D. (登録日: 2022-02-03, 公開日: 2023-02-15, 最終更新日: 2024-02-07)

• 主引用文献: Katariya, M.M.,Snee, M.,Tunnicliffe, R.B.,Kavanagh, M.E.,Boshoff, H.I.M.,Amadi, C.N.,Levy, C.W.,Munro, A.W.,Abell, C.,Leys, D.,Coyne, A.G.,McLean, K.J.; Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.; Chemistry, 29:e202203868-e202203868, 2023; PubMed: 36912255; DOI: 10.1002/chem.202203868

実験手法

X-RAY DIFFRACTION (2.24 Å)