7R0E

Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position

7R0E の概要

• エントリーDOI: 10.2210/pdb7r0e/pdb
• 関連するPDBエントリー: 7QTL
• EMDBエントリー: 14222
• 分子名称: Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total)
• 機能のキーワード: influenza, viral rna-dependent rna polymerase; antiviral drug; nucleoside analogue; t705 (favipiravir); t1106; cap-dependent transcription; backtracking;, viral protein
• 由来する生物種: Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 273743.61

構造登録者

Cusack, S.,Kouba, T. (登録日: 2022-02-01, 公開日: 2022-12-28, 最終更新日: 2024-07-17)

• 主引用文献: Kouba, T.,Dubankova, A.,Drncova, P.,Donati, E.,Vidossich, P.,Speranzini, V.,Pflug, A.,Huchting, J.,Meier, C.,De Vivo, M.,Cusack, S.; Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.; Cell Rep, 42:111901-111901, 2023; PubMed: 36596301; DOI: 10.1016/j.celrep.2022.111901

実験手法

ELECTRON MICROSCOPY (2.51 Å)