7QZI

BAZ2A bromodomain in complex with acetylpyrrole derivative compound 113

Summary for 7QZI

Entry DOI	10.2210/pdb7qzi/pdb
Related	7QYV 7QYW 7QZC
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, (2~{R})-~{N}-(2,2-dimethylpropyl)-1-[4-(4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrol-2-yl)-1,3-thiazol-2-yl]piperazine-2-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12881.84
Authors	Dalle Vedove, A.,Cazzanelli, G.,Caflisch, A.,Lolli, G. (deposition date: 2022-01-31, release date: 2022-09-28, Last modification date: 2024-01-31)
Primary citation	Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334 DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation