7QY0

X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 1

7QY0 の概要

• エントリーDOI: 10.2210/pdb7qy0/pdb
• 分子名称: Furin, N-[[1-[[2-[3,5-bis(chloranyl)phenyl]-6-[6-[4-(2-methoxyethyl)piperazin-4-ium-1-yl]pyridin-3-yl]oxy-pyridin-4-yl]methyl]piperidin-1-ium-4-yl]methyl]ethanamide, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: proprotein convertase, inhibitor, sars-cov-2, protease, complex, furin, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53679.58

構造登録者

Dahms, S.O.,Brandstetter, H.,Pautsch, A. (登録日: 2022-01-27, 公開日: 2022-04-20, 最終更新日: 2024-01-31)

• 主引用文献: Dahms, S.O.,Schnapp, G.,Winter, M.,Buttner, F.H.,Schleputz, M.,Gnamm, C.,Pautsch, A.,Brandstetter, H.; Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.; Acs Chem.Biol., 17:816-821, 2022; PubMed: 35377598; DOI: 10.1021/acschembio.2c00103

実験手法

X-RAY DIFFRACTION (1.54 Å)