7QWN
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
Summary for 7QWN
Entry DOI | 10.2210/pdb7qwn/pdb |
Related | 7QJL 7QKE 7QNN |
Descriptor | Steroid C26-monooxygenase, ethyl 5-pyridin-4-yl-1~{H}-indole-2-carboxylate, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | cyp, tuberculosis, mycobacterium, inhibitor, cholesterol, p450, cytochrome, tb, monooxygenase, cyp125, oxidoreductase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 3 |
Total formula weight | 143806.82 |
Authors | Snee, M.,Katariya, M.,Levy, C.,Leys, D. (deposition date: 2022-01-25, release date: 2023-02-01, Last modification date: 2024-02-07) |
Primary citation | Katariya, M.M.,Snee, M.,Tunnicliffe, R.B.,Kavanagh, M.E.,Boshoff, H.I.M.,Amadi, C.N.,Levy, C.W.,Munro, A.W.,Abell, C.,Leys, D.,Coyne, A.G.,McLean, K.J. Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29:e202203868-e202203868, 2023 Cited by PubMed: 36912255DOI: 10.1002/chem.202203868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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