7QUE
The STK17A (DRAK1) Kinase Domain Bound to CKJB68
Summary for 7QUE
Entry DOI | 10.2210/pdb7que/pdb |
Descriptor | Serine/threonine-protein kinase 17A, ~{N}-(phenylmethyl)-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide (3 entities in total) |
Functional Keywords | kinase small-molecule binder inhibitor macrocycle, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 63867.32 |
Authors | Mathea, S.,Preuss, F.,Chatterjee, D.,Dederer, V.,Kurz, C.G.,Amrhein, J.A.,Hanke, T.,Knapp, S. (deposition date: 2022-01-17, release date: 2022-02-02, Last modification date: 2024-01-31) |
Primary citation | Kurz, C.G.,Preuss, F.,Tjaden, A.,Cusack, M.,Amrhein, J.A.,Chatterjee, D.,Mathea, S.,Berger, L.M.,Berger, B.T.,Kramer, A.,Weller, M.,Weiss, T.,Muller, S.,Knapp, S.,Hanke, T. Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. J.Med.Chem., 65:7799-7817, 2022 Cited by PubMed: 35608370DOI: 10.1021/acs.jmedchem.2c00173 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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