7QRC

X-ray structure of Trypanosoma cruzi PEX14 in complex with a PEX5-PEX14 PPI inhibitor

7QRC の概要

• エントリーDOI: 10.2210/pdb7qrc/pdb
• 分子名称: Peroxin-14, GLYCEROL, ~{N}-(5-ethyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)-2-(4-fluorophenyl)ethanamide, ... (4 entities in total)
• 機能のキーワード: structure-based drug design, inhibitor, trypanosomiasis, complex, pex5-pex14 ppi, signaling protein
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15946.35

構造登録者

Napolitano, V.,Popowicz, G.M.,Dawidowski, M.,Dubin, G. (登録日: 2022-01-10, 公開日: 2022-11-23, 最終更新日: 2024-01-31)

• 主引用文献: Napolitano, V.,Mroz, P.,Marciniak, M.,Kalel, V.C.,Softley, C.A.,Janna Olmos, J.D.,Tippler, B.G.,Schorpp, K.,Rioton, S.,Frohlich, T.,Plettenburg, O.,Hadian, K.,Erdmann, R.,Sattler, M.,Popowicz, G.M.,Dawidowski, M.,Dubin, G.; Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.; Eur.J.Med.Chem., 243:114778-114778, 2022; PubMed: 36194937; DOI: 10.1016/j.ejmech.2022.114778

実験手法

X-RAY DIFFRACTION (2.18 Å)