7QRB
Crystal structure of CK1 delta in complex with PK-09-129
Summary for 7QRB
Entry DOI | 10.2210/pdb7qrb/pdb |
Descriptor | Casein kinase I isoform delta, SULFATE ION, 3-(dimethylamino)-~{N}-[4-[4-(4-fluorophenyl)-5-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)imidazol-1-yl]cyclohexyl]propane-1-sulfonamide, ... (4 entities in total) |
Functional Keywords | kinase, ck1d, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 140854.52 |
Authors | Chaikuad, A.,Khirsariya, P.,Paruch, K.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-01-10, release date: 2023-01-18, Last modification date: 2024-02-07) |
Primary citation | Nemec, V.,Khirsariya, P.,Janovska, P.,Moyano, P.M.,Maier, L.,Prochazkova, P.,Kebkova, P.,Gybel', T.,Berger, B.T.,Chaikuad, A.,Reinecke, M.,Kuster, B.,Knapp, S.,Bryja, V.,Paruch, K. Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. Angew.Chem.Int.Ed.Engl., 62:e202217532-e202217532, 2023 Cited by PubMed: 36625768DOI: 10.1002/anie.202217532 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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