7QK0
Crystal structure of human BCL6 BTB domain in complex with compound 12a
Summary for 7QK0
| Entry DOI | 10.2210/pdb7qk0/pdb |
| Descriptor | B-cell lymphoma 6 protein, (2~{S})-10-[[5-chloranyl-2-[(3~{S},5~{R})-3-methyl-5-oxidanyl-piperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | inhibitor, transcription |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 17361.81 |
| Authors | Gunnell, E.A.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2021-12-17, release date: 2022-06-15, Last modification date: 2024-01-31) |
| Primary citation | Huckvale, R.,Harnden, A.C.,Cheung, K.J.,Pierrat, O.A.,Talbot, R.,Box, G.M.,Henley, A.T.,de Haven Brandon, A.K.,Hallsworth, A.E.,Bright, M.D.,Akpinar, H.A.,Miller, D.S.J.,Tarantino, D.,Gowan, S.,Hayes, A.,Gunnell, E.A.,Brennan, A.,Davis, O.A.,Johnson, L.D.,de Klerk, S.,McAndrew, C.,Le Bihan, Y.V.,Meniconi, M.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Bellenie, B.R.,Hoelder, S. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo . J.Med.Chem., 65:8191-8207, 2022 Cited by PubMed Abstract: The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader to , a highly potent probe suitable for sustained depletion of BCL6 . We observed a sharp degradation SAR, where subtle structural changes conveyed the ability to induce degradation of BCL6. showed modest efficacy in a lymphoma xenograft mouse model following oral dosing. PubMed: 35653645DOI: 10.1021/acs.jmedchem.1c02175 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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