7QI0

Crystal structure of KLK6 in complex with compound DKFZ918

7QI0 の概要

• エントリーDOI: 10.2210/pdb7qi0/pdb
• 分子名称: Kallikrein-6, (5~{R})-3-(6-carbamimidoylpyridin-3-yl)-~{N}-[(1~{S})-1-naphthalen-1-ylpropyl]-2-oxidanylidene-1,3-oxazolidine-5-carboxamide (3 entities in total)
• 機能のキーワード: serine proteases, peptide binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49670.31

構造登録者

Jagtap, P.K.A.,Baumann, A.,Lohbeck, J.,Isak, D.,Miller, A.,Hennig, J. (登録日: 2021-12-14, 公開日: 2022-11-23, 最終更新日: 2024-01-31)

• 主引用文献: Baumann, A.,Isak, D.,Lohbeck, J.,Jagtap, P.K.A.,Hennig, J.,Miller, A.K.; Scalable synthesis and structural characterization of reversible KLK6 inhibitors.; Rsc Adv, 12:26989-26993, 2022; PubMed: 36320846; DOI: 10.1039/d2ra04670a

実験手法

X-RAY DIFFRACTION (1.88 Å)