7QHH

Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)

Summary for 7QHH

• Entry DOI: 10.2210/pdb7qhh/pdb
• Related: 7QHB
• EMDB information: 13969 13972 4572
• Descriptor: Isoform Flip of Glutamate receptor 1, Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-8 subunit, ... (7 entities in total)
• Functional Keywords: glutamate, ampa receptor, tarps, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 489472.63

Authors

Herguedas, B.,Kohegyi, B.,Dohrke, J.N.,Watson, J.F.,Zhang, D.,Ho, H.,Shaikh, S.,Lape, R.,Krieger, J.M.,Greger, I.H. (deposition date: 2021-12-12, release date: 2022-02-23)

• Primary citation: Herguedas, B.,Kohegyi, B.K.,Dohrke, J.N.,Watson, J.F.,Zhang, D.,Ho, H.,Shaikh, S.A.,Lape, R.,Krieger, J.M.,Greger, I.H.; Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.; Nat Commun, 13:734-734, 2022; PubMed: 35136046; DOI: 10.1038/s41467-022-28404-7

Experimental method

ELECTRON MICROSCOPY (3.6 Å)