7QGY

Human carbonic anhydrase II in complex with 3-((5-(ethoxycarbonyl)-4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid

7QGY の概要

• エントリーDOI: 10.2210/pdb7qgy/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 3-[(5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-yl)-(4-sulfamoylphenyl)amino]propanoic acid, ... (4 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29767.94

構造登録者

Paketuryte-Latve, V.,Smirnov, A.,Manakova, E.,Grazulis, S. (登録日: 2021-12-10, 公開日: 2022-05-04, 最終更新日: 2024-01-31)

• 主引用文献: Balandis, B.,Simkunas, T.,Paketuryte-Latve, V.,Michailoviene, V.,Mickeviciute, A.,Manakova, E.,Grazulis, S.,Belyakov, S.,Kairys, V.,Mickevicius, V.,Zubriene, A.,Matulis, D.; Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.; Pharmaceuticals, 15:-, 2022; PubMed: 35455474; DOI: 10.3390/ph15040477

実験手法

X-RAY DIFFRACTION (1.5 Å)