7QGW
Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections
Summary for 7QGW
Entry DOI | 10.2210/pdb7qgw/pdb |
Related PRD ID | PRD_002386 |
Descriptor | Cathepsin L2, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total) |
Functional Keywords | cathepsin, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 50193.11 |
Authors | Loboda, J.,Karnicar, K.,Lindic, N.,Usenik, A.,Lieske, J.,Meents, A.,Guenther, S.,Reinke, P.Y.A.,Falke, S.,Ewert, W.,Turk, D. (deposition date: 2021-12-10, release date: 2022-12-21, Last modification date: 2024-01-31) |
Primary citation | Reinke, P.Y.A.,de Souza, E.E.,Gunther, S.,Falke, S.,Lieske, J.,Ewert, W.,Loboda, J.,Herrmann, A.,Rahmani Mashhour, A.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Botosso, V.F.,Santelli, G.M.M.,Kapronezai, J.,de Araujo, M.V.,Silva-Pereira, T.T.,Filho, A.F.S.,Tavares, M.S.,Florez-Alvarez, L.,de Oliveira, D.B.L.,Durigon, E.L.,Giaretta, P.R.,Heinemann, M.B.,Hauser, M.,Seychell, B.,Bohler, H.,Rut, W.,Drag, M.,Beck, T.,Cox, R.,Chapman, H.N.,Betzel, C.,Brehm, W.,Hinrichs, W.,Ebert, G.,Latham, S.L.,Guimaraes, A.M.S.,Turk, D.,Wrenger, C.,Meents, A. Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections. Commun Biol, 6:1058-1058, 2023 Cited by PubMed: 37853179DOI: 10.1038/s42003-023-05317-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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