7QGW

Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections

Summary for 7QGW

• Entry DOI: 10.2210/pdb7qgw/pdb
• Related PRD ID: PRD_002386
• Descriptor: Cathepsin L2, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
• Functional Keywords: cathepsin, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50193.11

Authors

Loboda, J.,Karnicar, K.,Lindic, N.,Usenik, A.,Lieske, J.,Meents, A.,Guenther, S.,Reinke, P.Y.A.,Falke, S.,Ewert, W.,Turk, D. (deposition date: 2021-12-10, release date: 2022-12-21, Last modification date: 2024-01-31)

• Primary citation: Reinke, P.Y.A.,de Souza, E.E.,Gunther, S.,Falke, S.,Lieske, J.,Ewert, W.,Loboda, J.,Herrmann, A.,Rahmani Mashhour, A.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Botosso, V.F.,Santelli, G.M.M.,Kapronezai, J.,de Araujo, M.V.,Silva-Pereira, T.T.,Filho, A.F.S.,Tavares, M.S.,Florez-Alvarez, L.,de Oliveira, D.B.L.,Durigon, E.L.,Giaretta, P.R.,Heinemann, M.B.,Hauser, M.,Seychell, B.,Bohler, H.,Rut, W.,Drag, M.,Beck, T.,Cox, R.,Chapman, H.N.,Betzel, C.,Brehm, W.,Hinrichs, W.,Ebert, G.,Latham, S.L.,Guimaraes, A.M.S.,Turk, D.,Wrenger, C.,Meents, A.; Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.; Commun Biol, 6:1058-1058, 2023; PubMed: 37853179; DOI: 10.1038/s42003-023-05317-9

Experimental method

X-RAY DIFFRACTION (1.3 Å)