7QG5

IRAK4 in complex with inhibitor

7QG5 の概要

• エントリーDOI: 10.2210/pdb7qg5/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one (3 entities in total)
• 機能のキーワード: kinase inhibitor interleukin-1 receptor-associated kinase 4 interleukin-1 signaling, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70215.11

構造登録者

Xue, Y.,Aagaard, A.,Robb, G.R.,Degorce, S.L. (登録日: 2021-12-07, 公開日: 2022-05-04, 最終更新日: 2024-01-31)

• 主引用文献: Cumming, I.A.,Degorce, S.L.,Aagaard, A.,Braybrooke, E.L.,Davies, N.L.,Diene, C.R.,Eatherton, A.J.,Felstead, H.R.,Groombridge, S.D.,Lenz, E.M.,Li, Y.,Nai, Y.,Pearson, S.,Robb, G.R.,Scott, J.S.,Steward, O.R.,Wu, C.,Xue, Y.,Zhang, L.,Zhang, Y.; Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.; Bioorg.Med.Chem., 63:116729-116729, 2022; PubMed: 35439688; DOI: 10.1016/j.bmc.2022.116729

実験手法

X-RAY DIFFRACTION (2.3 Å)