7QCL

Structure of the MUCIN-2 Cterminal domains

Summary for 7QCL

• Entry DOI: 10.2210/pdb7qcl/pdb
• EMDB information: 13896
• Descriptor: Mucin-2, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: mucus, extracellular, net assemble, structural protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 151331.30

Authors

Gallego, P.,Hansson, G.C. (deposition date: 2021-11-24, release date: 2023-03-08, Last modification date: 2023-09-27)

• Primary citation: Gallego, P.,Garcia-Bonete, M.J.,Trillo-Muyo, S.,Recktenwald, C.V.,Johansson, M.E.V.,Hansson, G.C.; The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.; Nat Commun, 14:1969-1969, 2023; PubMed: 37031240; DOI: 10.1038/s41467-023-37666-8

Experimental method

ELECTRON MICROSCOPY (3.36 Å)