7QCI

Structure of SARS-CoV-2 Papain-like Protease bound to N-(3,4-dihydroxybenzylidene)-thiosemicarbazone

7QCI の概要

• エントリーDOI: 10.2210/pdb7qci/pdb
• 分子名称: Papain-like protease nsp3, N-(3,4-dihydroxybenzylidene)-thiosemicarbazone, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: cystein-protease, inhibitor, sars-cov-2, hydrazone, deubiquitination, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36686.70

構造登録者

Ewert, W.,Gunther, S.,Reinke, P.,Falke, S.,Lieske, J.,Miglioli, F.,Carcelli, M.,Srinivasan, V.,Betzel, C.,Han, H.,Lorenzen, K.,Guenther, C.,Niebling, S.,Garcia-Alai, M.,Hinrichs, W.,Rogolino, D.,Meents, A. (登録日: 2021-11-24, 公開日: 2022-03-16, 最終更新日: 2024-01-31)

• 主引用文献: Ewert, W.,Gunther, S.,Miglioli, F.,Falke, S.,Reinke, P.Y.A.,Niebling, S.,Gunther, C.,Han, H.,Srinivasan, V.,Brognaro, H.,Lieske, J.,Lorenzen, K.,Garcia-Alai, M.M.,Betzel, C.,Carcelli, M.,Hinrichs, W.,Rogolino, D.,Meents, A.; Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease.; Front Chem, 10:832431-832431, 2022; PubMed: 35480391; DOI: 10.3389/fchem.2022.832431

実験手法

X-RAY DIFFRACTION (1.76 Å)