7QBR

Human butyrylcholinesterase in complex with (Z)-N-tert-butyl-1-(8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinolin-2-yl)methanimine oxide

7QBR の概要

• エントリーDOI: 10.2210/pdb7qbr/pdb
• 分子名称: Cholinesterase, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: butyrylcholinesterase, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63950.29

構造登録者

Denic, M.,Chioua, M.,Knez, D.,Gobec, S.,Nachon, F.,Marco-Contelles, J.L.,Brazzolotto, X. (登録日: 2021-11-19, 公開日: 2022-11-30, 最終更新日: 2024-02-07)

• 主引用文献: Knez, D.,Diez-Iriepa, D.,Chioua, M.,Gottinger, A.,Denic, M.,Chantegreil, F.,Nachon, F.,Brazzolotto, X.,Skrzypczak-Wiercioch, A.,Meden, A.,Pislar, A.,Kos, J.,Zakelj, S.,Stojan, J.,Salat, K.,Serrano, J.,Fernandez, A.P.,Sanchez-Garcia, A.,Martinez-Murillo, R.,Binda, C.,Lopez-Munoz, F.,Gobec, S.,Marco-Contelles, J.; 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.; Acta Pharm Sin B, 13:2152-2175, 2023; PubMed: 37250172; DOI: 10.1016/j.apsb.2023.01.013

実験手法

X-RAY DIFFRACTION (2.13 Å)