7QBN

Structure of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303

7QBN の概要

• エントリーDOI: 10.2210/pdb7qbn/pdb
• 分子名称: Cathepsin K, (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: cathepsin k, protease inhibitor, cyanohydrazide warhead, azadipeptide nitrile, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24202.67

構造登録者

Benysek, J.,Busa, M.,Mares, M. (登録日: 2021-11-19, 公開日: 2022-01-26, 最終更新日: 2024-01-31)

• 主引用文献: Benysek, J.,Busa, M.,Rubesova, P.,Fanfrlik, J.,Lepsik, M.,Brynda, J.,Matouskova, Z.,Bartz, U.,Horn, M.,Gutschow, M.,Mares, M.; Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.; J Enzyme Inhib Med Chem, 37:515-526, 2022; PubMed: 35144520; DOI: 10.1080/14756366.2021.2024527

実験手法

X-RAY DIFFRACTION (1.55 Å)