7Q7U
Crystal structure of human BCL6 BTB domain in complex with compound 9a
Summary for 7Q7U
Entry DOI | 10.2210/pdb7q7u/pdb |
Descriptor | B-cell lymphoma 6 protein, 2-chloranyl-4-[[(2S)-2,7-dimethyl-6-oxidanylidene-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl]amino]pyridine-3-carbonitrile (3 entities in total) |
Functional Keywords | transcription, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16894.80 |
Authors | Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2021-11-09, release date: 2022-06-15, Last modification date: 2024-01-31) |
Primary citation | Davis, O.A.,Cheung, K.J.,Brennan, A.,Lloyd, M.G.,Rodrigues, M.J.,Pierrat, O.A.,Collie, G.W.,Le Bihan, Y.V.,Huckvale, R.,Harnden, A.C.,Varela, A.,Bright, M.D.,Eve, P.,Hayes, A.,Henley, A.T.,Carter, M.D.,McAndrew, P.C.,Talbot, R.,Burke, R.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Meniconi, M.,Bellenie, B.R.,Hoelder, S. Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J.Med.Chem., 65:8169-8190, 2022 Cited by PubMed: 35657291DOI: 10.1021/acs.jmedchem.1c02174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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