7Q7R

Crystal structure of human BCL6 BTB domain in complex with compound 1

7Q7R の概要

• エントリーDOI: 10.2210/pdb7q7r/pdb
• 分子名称: B-cell lymphoma 6 protein, 2-chloranyl-4-[[(2S)-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-6-oxidanylidene-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-10-yl]amino]pyridine-3-carbonitrile, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: transcription, inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16992.27

構造登録者

Le Bihan, Y.-V.,van Montfort, R.L.M. (登録日: 2021-11-09, 公開日: 2022-06-15, 最終更新日: 2024-01-31)

• 主引用文献: Davis, O.A.,Cheung, K.J.,Brennan, A.,Lloyd, M.G.,Rodrigues, M.J.,Pierrat, O.A.,Collie, G.W.,Le Bihan, Y.V.,Huckvale, R.,Harnden, A.C.,Varela, A.,Bright, M.D.,Eve, P.,Hayes, A.,Henley, A.T.,Carter, M.D.,McAndrew, P.C.,Talbot, R.,Burke, R.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Meniconi, M.,Bellenie, B.R.,Hoelder, S.; Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.; J.Med.Chem., 65:8169-8190, 2022; PubMed: 35657291; DOI: 10.1021/acs.jmedchem.1c02174

実験手法

X-RAY DIFFRACTION (1.7 Å)