7Q61

Structure of TEV conjugated A2ML1 (A2ML1-TC)

7Q61 の概要

• エントリーDOI: 10.2210/pdb7q61/pdb
• EMDBエントリー: 13849
• 分子名称: Alpha-2-macroglobulin-like protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: protease inhibitor, thioester, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 160851.71

構造登録者

Nielsen, N.S.,Zarantonello, A.,Andersen, G.R. (登録日: 2021-11-05, 公開日: 2022-04-20, 最終更新日: 2022-11-02)

• 主引用文献: Nielsen, N.S.,Zarantonello, A.,Harwood, S.L.,Jensen, K.T.,Kjoge, K.,Thogersen, I.B.,Schauser, L.,Karlsen, J.L.,Andersen, G.R.,Enghild, J.J.; Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.; Nat Commun, 13:3033-3033, 2022; PubMed: 35641520; DOI: 10.1038/s41467-022-30758-x

実験手法

ELECTRON MICROSCOPY (2.88 Å)