7Q5I
A glucose-based molecular rotor probes the catalytic site of glycogen phosphorylase.
This is a non-PDB format compatible entry.
Summary for 7Q5I
Entry DOI | 10.2210/pdb7q5i/pdb |
Descriptor | Glycogen phosphorylase, muscle form, 2-cyano-3-[4-(dimethylamino)phenyl]-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]propanamide, CARBONATE ION, ... (5 entities in total) |
Functional Keywords | glycogen phosphorylase, inhibitor, type 2 diabetes, molecular rotors, sugar binding protein |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 98286.07 |
Authors | Neofytos, D.D.,Chrysina, E.D. (deposition date: 2021-11-03, release date: 2022-03-02, Last modification date: 2024-01-31) |
Primary citation | Minadakis, M.P.,Mavreas, K.F.,Neofytos, D.D.,Paschou, M.,Kogkaki, A.,Athanasiou, V.,Mamais, M.,Veclani, D.,Iatrou, H.,Venturini, A.,Chrysina, E.D.,Papazafiri, P.,Gimisis, T. A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function. Org.Biomol.Chem., 20:2407-2423, 2022 Cited by PubMed: 35119451DOI: 10.1039/d1ob02211c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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