7Q4B
Type I beta-amyloid 42 Filaments from Human Brain
Summary for 7Q4B
Entry DOI | 10.2210/pdb7q4b/pdb |
EMDB information | 13800 |
Descriptor | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION (3 entities in total) |
Functional Keywords | amyloid filaments, abeta42, human brain, cryo-em, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 10 |
Total formula weight | 45200.87 |
Authors | Yang, Y.,Arseni, D.,Zhang, W.,Huang, M.,Lovestam, S.K.A.,Schweighauser, M.,Kotecha, A.,Murzin, A.G.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Garringer, H.J.,Gelpi, E.,Newell, K.L.,Kovacs, G.G.,Vidal, R.,Ghetti, B.,Falcon, B.,Scheres, S.H.W.,Goedert, M. (deposition date: 2021-10-30, release date: 2021-11-24, Last modification date: 2024-07-17) |
Primary citation | Yang, Y.,Arseni, D.,Zhang, W.,Huang, M.,Lovestam, S.,Schweighauser, M.,Kotecha, A.,Murzin, A.G.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Garringer, H.J.,Gelpi, E.,Newell, K.L.,Kovacs, G.G.,Vidal, R.,Ghetti, B.,Ryskeldi-Falcon, B.,Scheres, S.H.W.,Goedert, M. Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375:167-172, 2022 Cited by PubMed: 35025654DOI: 10.1126/science.abm7285 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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