7Q1M

Crystal structure of human butyrylcholinesterase in complex with N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide

7Q1M の概要

• エントリーDOI: 10.2210/pdb7q1m/pdb
• 分子名称: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: butyrylcholinesterase, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62859.09

構造登録者

Brazzolotto, X.,Panek, D.,Pasieka, A.,Malawska, B.,Nachon, F. (登録日: 2021-10-20, 公開日: 2022-11-16, 最終更新日: 2024-02-07)

• 主引用文献: Panek, D.,Pasieka, A.,Latacz, G.,Zareba, P.,Szczech, M.,Godyn, J.,Chantegreil, F.,Nachon, F.,Brazzolotto, X.,Skrzypczak-Wiercioch, A.,Walczak, M.,Smolik, M.,Salat, K.,Hofner, G.,Wanner, K.,Wieckowska, A.,Malawska, B.; Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.; Eur.J.Med.Chem., 249:115135-115135, 2023; PubMed: 36696766; DOI: 10.1016/j.ejmech.2023.115135

実験手法

X-RAY DIFFRACTION (2.79 Å)