7Q1B

Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat

7Q1B の概要

• エントリーDOI: 10.2210/pdb7q1b/pdb
• 分子名称: Histone deacetylase DAC2, ZINC ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: epigenetics, trypanosoma cruzi, histone deacetylase, dac2, pathogen, hydrolase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51038.92

構造登録者

Marek, M.,Ramos-Morales, E.,Romier, C. (登録日: 2021-10-18, 公開日: 2021-12-15, 最終更新日: 2024-01-31)

• 主引用文献: Marek, M.,Ramos-Morales, E.,Picchi-Constante, G.F.A.,Bayer, T.,Norstrom, C.,Herp, D.,Sales-Junior, P.A.,Guerra-Slompo, E.P.,Hausmann, K.,Chakrabarti, A.,Shaik, T.B.,Merz, A.,Troesch, E.,Schmidtkunz, K.,Goldenberg, S.,Pierce, R.J.,Mourao, M.M.,Jung, M.,Schultz, J.,Sippl, W.,Zanchin, N.I.T.,Romier, C.; Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.; Cell Rep, 37:110129-110129, 2021; PubMed: 34936867; DOI: 10.1016/j.celrep.2021.110129

実験手法

X-RAY DIFFRACTION (1.75 Å)