7Q14

Crystal Structure of a Class D Carbapenemase_K73ALY Complexed with Imipenem

This is a non-PDB format compatible entry.

Summary for 7Q14

• Entry DOI: 10.2210/pdb7q14/pdb
• Descriptor: Beta-lactamase, Imipenem, 1-BUTANOL, ... (5 entities in total)
• Functional Keywords: oxa, imipenem, k73aly, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 8
• Total formula weight: 246276.46

Authors

Zhou, Q.,He, Y.,Jin, Y. (deposition date: 2021-10-18, release date: 2022-11-16, Last modification date: 2024-03-06)

• Primary citation: Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y.; An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity; Acs Cent.Sci., 2023; DOI: 10.1021/acscentsci.3c00609

Experimental method

X-RAY DIFFRACTION (2.15 Å)