7PWU

PARP15 catalytic domain in complex with OUL256

Summary for 7PWU

Entry DOI	10.2210/pdb7pwu/pdb
Related	7PW3 7PWA 7PWC 7PWK 7PWL 7PWM 7PWP 7PWQ 7PWR 7PWS
Descriptor	Protein mono-ADP-ribosyltransferase PARP15, 6-(cyclopropylmethoxy)phthalazine-1,4-dione (3 entities in total)
Functional Keywords	adp-ribosyltransferase, inhibitor, complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	51109.14
Authors	Maksimainen, M.M.,Lehtio, L. (deposition date: 2021-10-07, release date: 2022-05-11, Last modification date: 2024-01-31)
Primary citation	Nizi, M.G.,Maksimainen, M.M.,Murthy, S.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Sowa, S.T.,Galera-Prat, A.,Prunskaite-Hyyrylainen, R.,Luscher, B.,Korn, P.,Lehtio, L.,Tabarrini, O. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur.J.Med.Chem., 237:114362-114362, 2022 Cited by PubMed: 35500474 DOI: 10.1016/j.ejmech.2022.114362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation