7PWK

PARP15 catalytic domain in complex with OUL239

Summary for 7PWK

• Entry DOI: 10.2210/pdb7pwk/pdb
• Related: 7PW3 7PWA 7PWC
• Descriptor: Protein mono-ADP-ribosyltransferase PARP15, 4-(cyclopropylmethoxy)benzamide (3 entities in total)
• Functional Keywords: adp-ribosyltransferase, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 51070.14

Authors

Maksimainen, M.M.,Lehtio, L. (deposition date: 2021-10-07, release date: 2022-05-11, Last modification date: 2024-01-31)

• Primary citation: Nizi, M.G.,Maksimainen, M.M.,Murthy, S.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Sowa, S.T.,Galera-Prat, A.,Prunskaite-Hyyrylainen, R.,Luscher, B.,Korn, P.,Lehtio, L.,Tabarrini, O.; Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15.; Eur.J.Med.Chem., 237:114362-114362, 2022; PubMed: 35500474; DOI: 10.1016/j.ejmech.2022.114362

Experimental method

X-RAY DIFFRACTION (1.8 Å)