7PW5

Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor

Summary for 7PW5

Entry DOI	10.2210/pdb7pw5/pdb
EMDB information	13675
Descriptor	SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1, Protein SMG8, Protein SMG9, ... (7 entities in total)
Functional Keywords	complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	566696.19
Authors	Langer, L.M.,Conti, E. (deposition date: 2021-10-06, release date: 2021-12-01)
Primary citation	Langer, L.M.,Bonneau, F.,Gat, Y.,Conti, E. Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10:-, 2021 Cited by PubMed: 34698635 DOI: 10.7554/eLife.72353 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation