7PQK

Co-Crystal Structure of M. tuberculosis LeuRS in Complex with the Adduct Formed by Prodrug Cmpd1 with Adenosine-monophosphate

7PQK の概要

• エントリーDOI: 10.2210/pdb7pqk/pdb
• 分子名称: Leucine--tRNA ligase, (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: leucyl-trna synthetase, catalyses the reaction: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu) leucine-trna ligase atp binding domain, ligase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25568.59

構造登録者

Palencia, A.,Cusack, S. (登録日: 2021-09-17, 公開日: 2023-01-18, 最終更新日: 2024-02-07)

• 主引用文献: Hoffmann, G.,Le Gorrec, M.,Mestdach, E.,Cusack, S.,Salmon, L.,Jensen, M.R.,Palencia, A.; Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase.; J.Am.Chem.Soc., 145:800-810, 2023; PubMed: 36599057; DOI: 10.1021/jacs.2c04808

実験手法

X-RAY DIFFRACTION (1.15 Å)