7PPY
CARM1 in complex with EML709
Summary for 7PPY
Entry DOI | 10.2210/pdb7ppy/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, methyl 6-[4-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protein arginine n-methyltransferase, prmt4, carm1, inhibitor, transcription |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 4 |
Total formula weight | 166637.17 |
Authors | Marechal, N.,Cura, V.,Bonnefond, L.,Troffer-Charlier, N.,Cavarelli, J. (deposition date: 2021-09-15, release date: 2022-04-06, Last modification date: 2024-01-31) |
Primary citation | Iannelli, G.,Milite, C.,Marechal, N.,Cura, V.,Bonnefond, L.,Troffer-Charlier, N.,Feoli, A.,Rescigno, D.,Wang, Y.,Cipriano, A.,Viviano, M.,Bedford, M.T.,Cavarelli, J.,Castellano, S.,Sbardella, G. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65:11574-11606, 2022 Cited by PubMed: 35482954DOI: 10.1021/acs.jmedchem.2c00252 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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