7POS
PI3 kinase delta in complex with 5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-N-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1-yl}pyridin-3-yl)pyridine-3-sulfonamide
7POS の概要
エントリーDOI | 10.2210/pdb7pos/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 5-(3,6-dihydro-2~{H}-pyran-4-yl)-2-methoxy-~{N}-[5-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]pyridin-3-yl]pyridine-3-sulfonamide (3 entities in total) |
機能のキーワード | pi3 kinase delta, signaling protein |
由来する生物種 | Mus musculus (Mouse) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 108335.30 |
構造登録者 | |
主引用文献 | Down, K.,Amour, A.,Anderson, N.A.,Barton, N.,Campos, S.,Cannons, E.P.,Clissold, C.,Convery, M.A.,Coward, J.J.,Doyle, K.,Duempelfeld, B.,Edwards, C.D.,Goldsmith, M.D.,Krause, J.,Mallett, D.N.,McGonagle, G.A.,Patel, V.K.,Rowedder, J.,Rowland, P.,Sharpe, A.,Sriskantharajah, S.,Thomas, D.A.,Thomson, D.W.,Uddin, S.,Hamblin, J.N.,Hessel, E.M. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode. J.Med.Chem., 64:13780-13792, 2021 Cited by PubMed: 34510892DOI: 10.1021/acs.jmedchem.1c01102 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.493 Å) |
構造検証レポート
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