7POC

An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles

7POC の概要

• エントリーDOI: 10.2210/pdb7poc/pdb
• 分子名称: 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
• 機能のキーワード: biocatalyst, cascade, chemo-enzymatic, thermophilic, promiscuous, alpha-oxoamine synthase, pyrrole, synthase
• 由来する生物種: Thermus thermophilus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 187329.15

構造登録者

Basle, A.,Ashley, B.,Campopiano, D.,Marles-Wright, J. (登録日: 2021-09-08, 公開日: 2022-09-21, 最終更新日: 2024-02-28)

• 主引用文献: Ashley, B.,Basle, A.,Sajjad, M.,El Ashram, A.,Kelis, P.,Marles-Wright, J.,Campopiano, D.J.; Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming alpha-Oxoamine Synthase.; Acs Sustain Chem Eng, 11:7997-8002, 2023; PubMed: 37266354; DOI: 10.1021/acssuschemeng.3c00243

実験手法

X-RAY DIFFRACTION (2.6 Å)