7PMT

Human Cyclophilin D in complex with N-[(5-ethyl-4-oxo-1,2,3,4,5,6- hexahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide

7PMT の概要

• エントリーDOI: 10.2210/pdb7pmt/pdb
• 関連するPDBエントリー: 7NHB 7NMR 7O02 7O3G 7OGI
• 分子名称: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, DIMETHYL SULFOXIDE, ~{N}-[(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxidanylidene-1,3-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: cyclophilin d ppiase, isomerase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18270.92

構造登録者

Silva, D.O.,Graedler, U.,Bandeiras, T.M. (登録日: 2021-09-02, 公開日: 2022-09-14, 最終更新日: 2026-04-01)

• 主引用文献: Silva, D.O.,Freitas, M.C.,Malta, C.F.,Martins, M.T.,Sousa, P.M.,Matias, P.M.,Schwarz, D.,Ventura, M.R.,Gradler, U.,Bandeiras, T.M.; Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site; Int.J.Biol.Macromol., :151496-, 2026; DOI: 10.1016/j.ijbiomac.2026.151496

実験手法

X-RAY DIFFRACTION (0.98 Å)