7PJR

Notum_ARUK3000438

7PJR の概要

• エントリーDOI: 10.2210/pdb7pjr/pdb
• 分子名称: Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: notum inhibitor, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44576.48

構造登録者

Vecchia, L.,Zhao, Y.,Fish, P.,Jones, E.Y. (登録日: 2021-08-24, 公開日: 2022-09-07, 最終更新日: 2023-03-22)

• 主引用文献: Willis, N.J.,Mahy, W.,Sipthorp, J.,Zhao, Y.,Woodward, H.L.,Atkinson, B.N.,Bayle, E.D.,Svensson, F.,Frew, S.,Jeganathan, F.,Monaghan, A.,Benvegnu, S.,Jolly, S.,Vecchia, L.,Ruza, R.R.,Kjaer, S.,Howell, S.,Snijders, A.P.,Bictash, M.,Salinas, P.C.,Vincent, J.P.,Jones, E.Y.,Whiting, P.,Fish, P.V.; Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.; J.Med.Chem., 65:7212-7230, 2022; PubMed: 35536179; DOI: 10.1021/acs.jmedchem.2c00162

実験手法

X-RAY DIFFRACTION (1.51 Å)