7PIE

Protein kinase A catalytic subunit in complex with PKI5-24 and EN068

7PIE の概要

• エントリーDOI: 10.2210/pdb7pie/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 2-azanyl-5-[3-[(2R)-morpholin-2-yl]phenyl]benzenecarbonitrile, ... (5 entities in total)
• 機能のキーワード: protein kinase, ligand complex, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43817.67

構造登録者

Glinca, S.,Mueller, J.M.,Ruf, M.,Merkl, S. (登録日: 2021-08-19, 公開日: 2022-09-21, 最終更新日: 2024-02-07)

• 主引用文献: Muller, J.,Klein, R.,Tarkhanova, O.,Gryniukova, A.,Borysko, P.,Merkl, S.,Ruf, M.,Neumann, A.,Gastreich, M.,Moroz, Y.S.,Klebe, G.,Glinca, S.; Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces.; J.Med.Chem., 65:15663-15678, 2022; PubMed: 36069712; DOI: 10.1021/acs.jmedchem.2c00813

実験手法

X-RAY DIFFRACTION (1.427 Å)