7PGK

HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS

7PGK の概要

• エントリーDOI: 10.2210/pdb7pgk/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900013
• 分子名称: Hedgehog-interacting protein, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose (2 entities in total)
• 機能のキーワード: hhip, hedgehog, morphogen, signalling, glycosaminoglycan, cholesterol, palmitate, secreted, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22067.94

構造登録者

Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinuskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. (登録日: 2021-08-14, 公開日: 2021-12-15, 最終更新日: 2021-12-22)

• 主引用文献: Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinauskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C.; Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.; Nat Commun, 12:7171-7171, 2021; PubMed: 34887403; DOI: 10.1038/s41467-021-27475-2

実験手法

X-RAY DIFFRACTION (2.75 Å)