7PFS
Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide ((1R)-1-Amino-3-phenylpropyl){2-([1,1:3,1-terphenyl]-5-ylmethyl)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)-amino]-3-oxopropyl}phosphinic acid
Summary for 7PFS
Entry DOI | 10.2210/pdb7pfs/pdb |
Related | 5AB0 |
Descriptor | Endoplasmic reticulum aminopeptidase 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | erap2, transition state analogues, antigen presentation, hydrolase, phosphinic pseudotripeptides, aminopeptidase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 230221.34 |
Authors | Giastas, P.,Stratikos, E.,Mpakali, A. (deposition date: 2021-08-12, release date: 2022-01-26, Last modification date: 2024-01-31) |
Primary citation | Mpakali, A.,Georgiadis, D.,Stratikos, E.,Giastas, P. Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13:218-224, 2022 Cited by PubMed: 35178178DOI: 10.1021/acsmedchemlett.1c00582 PDB entries with the same primary citation |
Experimental method |
Structure validation
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