7PFS

Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide ((1R)-1-Amino-3-phenylpropyl){2-([1,1:3,1-terphenyl]-5-ylmethyl)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)-amino]-3-oxopropyl}phosphinic acid

Summary for 7PFS

• Entry DOI: 10.2210/pdb7pfs/pdb
• Related: 5AB0
• Descriptor: Endoplasmic reticulum aminopeptidase 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: erap2, transition state analogues, antigen presentation, hydrolase, phosphinic pseudotripeptides, aminopeptidase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 230221.34

Authors

Giastas, P.,Stratikos, E.,Mpakali, A. (deposition date: 2021-08-12, release date: 2022-01-26, Last modification date: 2024-01-31)

• Primary citation: Mpakali, A.,Georgiadis, D.,Stratikos, E.,Giastas, P.; Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.; Acs Med.Chem.Lett., 13:218-224, 2022; PubMed: 35178178; DOI: 10.1021/acsmedchemlett.1c00582

Experimental method

X-RAY DIFFRACTION (2.7 Å)