7PDR

Crystal structure of Lymnaea stagnalis Acetylcholine-binding protein (Ls-AChBP) Q55R/M114V double mutant complexed with Dichloromezotiaz

これはPDB形式変換不可エントリーです。

7PDR の概要

• エントリーDOI: 10.2210/pdb7pdr/pdb
• 分子名称: Acetylcholine-binding protein, 3-[3,5-bis(chloranyl)phenyl]-1-[(2-chloranyl-1,3-thiazol-5-yl)methyl]-9-methyl-pyrido[1,2-a]pyrimidine-2,4-dione (3 entities in total)
• 機能のキーワード: acetylcholine, protein, insecticide, signaling protein
• 由来する生物種: Lymnaea stagnalis (Great pond snail, Helix stagnalis)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 121355.85

構造登録者

Montgomery, M.G. (登録日: 2021-08-06, 公開日: 2022-02-02, 最終更新日: 2024-01-31)

• 主引用文献: Montgomery, M.,Rendine, S.,Zimmer, C.T.,Elias, J.,Schaetzer, J.,Pitterna, T.,Benfatti, F.,Skaljac, M.,Bigot, A.; Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators.; J.Med.Chem., 65:2297-2312, 2022; PubMed: 34986308; DOI: 10.1021/acs.jmedchem.1c01767

実験手法

X-RAY DIFFRACTION (2.33 Å)