7PDJ

R12E vFLIP mutant

Summary for 7PDJ

Entry DOI	10.2210/pdb7pdj/pdb
Related	3CL3 5LDE
Descriptor	FLICE inhibitory protein (1 entity in total)
Functional Keywords	kshv virus, tandem ded protein, nf-kappab activation, ikk kinase binding, ikkgamma, viral protein
Biological source	Human herpesvirus 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus)
Total number of polymer chains	6
Total formula weight	131264.20
Authors	Barrett, T.E. (deposition date: 2021-08-05, release date: 2022-05-11, Last modification date: 2024-02-07)
Primary citation	Bagneris, C.,Senthil Kumar, S.L.,Baratchian, M.,Britt, H.M.,Assafa, T.E.,Thalassinos, K.,Collins, M.K.,Barrett, T.E. Mechanistic insights into the activation of the IKK kinase complex by the Kaposi's sarcoma herpes virus oncoprotein vFLIP. J.Biol.Chem., 298:102012-102012, 2022 Cited by PubMed: 35525271 DOI: 10.1016/j.jbc.2022.102012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.2 Å)

Structure validation