7PAE

The crystal structure of Deltarasin in complex with PDE6D

7PAE の概要

• エントリーDOI: 10.2210/pdb7pae/pdb
• 分子名称: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, deltarasin, ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20016.80

構造登録者

Beaumont, E.,Williams, D. (登録日: 2021-07-29, 公開日: 2022-06-08, 最終更新日: 2024-01-31)

• 主引用文献: Canovas Nunes, S.,De Vita, S.,Anighoro, A.,Autelitano, F.,Beaumont, E.,Klingbeil, P.,McGuinness, M.,Duvert, B.,Harris, C.,Yang, L.,Pokharel, S.P.,Chen, C.W.,Ermann, M.,Williams, D.A.,Xu, H.; Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects.; Blood Cancer J, 12:64-64, 2022; PubMed: 35422065; DOI: 10.1038/s41408-022-00663-z

実験手法

X-RAY DIFFRACTION (1.85 Å)