7P85

Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate

7P85 の概要

• エントリーDOI: 10.2210/pdb7p85/pdb
• 関連するPDBエントリー: 1PSC
• 分子名称: Parathion hydrolase, ethyl-4-methylbenzylphosphonate, FORMIC ACID, ... (7 entities in total)
• 機能のキーワード: bioscavenger, enzyme engineering, organophosphate hydrolase, organophosphorous compound, phosphotriesterase, hydrolase
• 由来する生物種: Brevundimonas diminuta (Pseudomonas diminuta)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38639.95

構造登録者

Eichinger, A.,Skerra, A. (登録日: 2021-07-21, 公開日: 2022-08-03, 最終更新日: 2024-02-07)

• 主引用文献: Job, L.,Kohler, A.,Eichinger, A.,Testanera, M.,Escher, B.,Worek, F.,Skerra, A.; Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop.; Biochemistry, 62:942-955, 2023; PubMed: 36752589; DOI: 10.1021/acs.biochem.2c00666

実験手法

X-RAY DIFFRACTION (1.47 Å)