7P60
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio
Summary for 7P60
Entry DOI | 10.2210/pdb7p60/pdb |
EMDB information | 13202 13203 13208 13212 13213 |
Descriptor | Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb4 (2 entities in total) |
Functional Keywords | lrrc8 family, volume-regulated anion channel, leucine-rich repeat, sybody, cryo-em, membrane protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 9 |
Total formula weight | 615873.10 |
Authors | Deneka, D.,Rutz, S.,Sawicka, M. (deposition date: 2021-07-15, release date: 2021-09-15, Last modification date: 2021-10-13) |
Primary citation | Deneka, D.,Rutz, S.,Hutter, C.A.J.,Seeger, M.A.,Sawicka, M.,Dutzler, R. Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains. Nat Commun, 12:5435-5435, 2021 Cited by PubMed: 34521847DOI: 10.1038/s41467-021-25742-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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