7P5Y

Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3

Summary for 7P5Y

• Entry DOI: 10.2210/pdb7p5y/pdb
• EMDB information: 13202 13203 13208
• Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb3 (2 entities in total)
• Functional Keywords: lrrc8 family, volume-regulated anion channel, leucine-rich repeat, sybody, cryo-em, membrane protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 12
• Total formula weight: 664142.23

Authors

Deneka, D.,Rutz, S.,Sawicka, M. (deposition date: 2021-07-15, release date: 2021-09-15, Last modification date: 2021-10-13)

• Primary citation: Deneka, D.,Rutz, S.,Hutter, C.A.J.,Seeger, M.A.,Sawicka, M.,Dutzler, R.; Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.; Nat Commun, 12:5435-5435, 2021; PubMed: 34521847; DOI: 10.1038/s41467-021-25742-w

Experimental method

ELECTRON MICROSCOPY (3.29 Å)