7P5P
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Summary for 7P5P
Entry DOI | 10.2210/pdb7p5p/pdb |
Descriptor | Kelch-like ECH-associated protein 1, CHLORIDE ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | protein ubiquitination, protein-protein interaction, oxidative stress, protein binding |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 35921.53 |
Authors | Davies, T.G. (deposition date: 2021-07-14, release date: 2021-11-17, Last modification date: 2024-06-19) |
Primary citation | Norton, D.,Bonnette, W.G.,Callahan, J.F.,Carr, M.G.,Griffiths-Jones, C.M.,Heightman, T.D.,Kerns, J.K.,Nie, H.,Rich, S.J.,Richardson, C.,Rumsey, W.,Sanchez, Y.,Verdonk, M.L.,Willems, H.M.G.,Wixted, W.E.,Wolfe 3rd, L.,Woolford, A.J.,Wu, Z.,Davies, T.G. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J.Med.Chem., 64:15949-15972, 2021 Cited by PubMed: 34705450DOI: 10.1021/acs.jmedchem.1c01351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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