7P5P

Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction

7P5P の概要

• エントリーDOI: 10.2210/pdb7p5p/pdb
• 分子名称: Kelch-like ECH-associated protein 1, CHLORIDE ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein ubiquitination, protein-protein interaction, oxidative stress, protein binding
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35921.53

構造登録者

Davies, T.G. (登録日: 2021-07-14, 公開日: 2021-11-17, 最終更新日: 2021-11-24)

• 主引用文献: Norton, D.,Bonnette, W.G.,Callahan, J.F.,Carr, M.G.,Griffiths-Jones, C.M.,Heightman, T.D.,Kerns, J.K.,Nie, H.,Rich, S.J.,Richardson, C.,Rumsey, W.,Sanchez, Y.,Verdonk, M.L.,Willems, H.M.G.,Wixted, W.E.,Wolfe 3rd, L.,Woolford, A.J.,Wu, Z.,Davies, T.G.; Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.; J.Med.Chem., 64:15949-15972, 2021; PubMed: 34705450; DOI: 10.1021/acs.jmedchem.1c01351

実験手法

X-RAY DIFFRACTION (1.85 Å)