7P4F
Crystal Structure of Monoamine Oxidase B in complex with inhibitor 1
Summary for 7P4F
Entry DOI | 10.2210/pdb7p4f/pdb |
Descriptor | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl)amino]methyl]phenyl]methoxy]chromen-2-one, ... (5 entities in total) |
Functional Keywords | monoamine oxidase, drug target, neurodegeneration, mitochondrial membrane, flavoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 120750.63 |
Authors | Iacovino, L.G.,Binda, C.,Pisani, L. (deposition date: 2021-07-11, release date: 2022-05-18, Last modification date: 2024-01-31) |
Primary citation | Ekstrom, F.,Gottinger, A.,Forsgren, N.,Catto, M.,Iacovino, L.G.,Pisani, L.,Binda, C. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. Acs Med.Chem.Lett., 13:499-506, 2022 Cited by PubMed: 35300078DOI: 10.1021/acsmedchemlett.2c00001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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