7P2U

Crystal structure of Schistosoma mansoni HDAC8 in complex with a 3-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site

7P2U の概要

• エントリーDOI: 10.2210/pdb7p2u/pdb
• 分子名称: Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: smhdac8, novel binding-site, hdaci, histone-deacetilase inhibitor complex, hydrolase
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50670.47

構造登録者

Saccoccia, F.,Gemma, S.,Campiani, G.,Ruberti, G. (登録日: 2021-07-06, 公開日: 2022-07-20, 最終更新日: 2024-01-31)

• 主引用文献: Saccoccia, F.,Pozzetti, L.,Gimmelli, R.,Butini, S.,Guidi, A.,Papoff, G.,Giannaccari, M.,Brogi, S.,Scognamiglio, V.,Gemma, S.,Ruberti, G.,Campiani, G.; Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.; J.Biol.Chem., 298:102375-102375, 2022; PubMed: 35970392; DOI: 10.1016/j.jbc.2022.102375

実験手法

X-RAY DIFFRACTION (1.8 Å)