7P1M

Galectin-8 N-terminal carbohydrate recognition domain in complex with benzimidazole D-galactal ligand

7P1M の概要

• エントリーDOI: 10.2210/pdb7p1m/pdb
• 分子名称: Galectin-8, 2-[[(2R,3R,4R)-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2H-pyran-4-yl]oxymethyl]-3-methyl-benzimidazole-5-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, galectin, lectin, d-galactal, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34867.25

構造登録者

Hassan, M.,Hakansson, M.,Nilsson, J.U.,Kovacic, R. (登録日: 2021-07-02, 公開日: 2021-12-15, 最終更新日: 2024-01-31)

• 主引用文献: Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J.; Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.; Acs Med.Chem.Lett., 12:1745-1752, 2021; PubMed: 34795863; DOI: 10.1021/acsmedchemlett.1c00371

実験手法

X-RAY DIFFRACTION (1.52 Å)